Fibrinogen Versus Fresh Frozen Plasma on the Patients’ Outcome with Hemorrhagic Shock Induce Chronic Diseases Caused by Multiple Trauma: A Randomized, Double-blinded, Clinical Trial Study

نویسندگان

چکیده

Objectives: The current study aimed to investigate the effect of fibrinogen compared fresh frozen plasma (FFP) on outcomes patients with traumatic hemorrhagic shock (THS). Methods: In this double-blind RCT study, chronic diseases referred emergency department (ED) were evaluated. Patients randomly divided into three equal groups; first group received concentrate (70 mg/kg), second was treated FFP, and third crystalloid. Transfusion FFP packed red blood cells (PRBC) in a 1:1 ratio. need for admission intensive care units, PRBC transfusion multiple organ failure, hospitalization days, mortality rate both groups. Results: total, 45 studied. number (RBCs) transfused crystalloid, Fibrinogen 2.93, 2.37, 2, respectively, which statistically significant (P = 0.03). Two (13.3%) Fibrinogen-treated group, 4 (26%) 2 control had failure 0.5). incidence sepsis significantly higher FFP-treated group. addition, who crystalloid (46.7%) 0.13). Conclusions: This demonstrated that treating associated decreased pRBC units mortality. Therefore, management not only can improve but also declines patients’ exposure allogeneic products.

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ژورنال

عنوان ژورنال: Jundishapur Journal of Chronic Disease Care

سال: 2021

ISSN: ['2322-4207', '2322-3758']

DOI: https://doi.org/10.5812/jjcdc.110313